304-52-9

304-52-9 structure

Name: α-Methyl-5-hydroxytryptamine maleate
Chemical Name: α-Methyl-5-hydroxytryptamine maleate
CAS Number: 304-52-9
Molecular Formula: C₁₅H₁₈N₂O₅
Molecular Weight: 306.31400
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-12-13 08:42:41
Modify Date: 2024-01-17 15:34:02
α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor.α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan.α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis[1][2][3].

Name	α-Methyl-5-hydroxytryptamine maleate
Synonyms	MFCD00082468 4a-methyl-5-hydroxytryptamine a-Methyl-5-hydroxytryptaminemaleate

Description	α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor.α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan.α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Dobbins DE. Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb. Am J Physiol. 1998 Feb;274(2):H650-4. [2]. Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119(3):821-33. [3]. Edwards E, et al. (+/-)-1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane(DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31(7):615-21.

Safety Phrases	22-24/25
WGK Germany	3

108477-22-1

304-52-9

Literature: Ismaiel; Titeler; Miller; Smith; Glennon Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758

Precursor 1
108477-22-1
DownStream 0