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74209-34-0

74209-34-0 structure
74209-34-0 structure
  • Name: 3-Bromo-7-nitro-1H-indazole
  • Chemical Name: 3-Bromo-7-nitro-1H-indazole
  • CAS Number: 74209-34-0
  • Molecular Formula: C7H4BrN3O2
  • Molecular Weight: 242.030
  • Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
  • Create Date: 2018-06-03 08:00:00
  • Modify Date: 2024-01-08 18:58:50
  • 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1].

Name 3-Bromo-7-nitro-1H-indazole
Synonyms 3-bromo-7-nitro-2H-indazole
3-Bromo-7-nitro-1H-indazole
MFCD00159910
1H-Indazole, 3-bromo-7-nitro-
Description 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1].
Related Catalog
Target

nNOS[1]

References

[1]. Gocmez SS, et al. The effect of a selective neuronal nitric oxide synthase inhibitor 3-bromo 7-nitroindazoleon spatial learning and memory in rats. Pharmacol Biochem Behav. 2015 Apr;131:19-25.

Density 2.0±0.1 g/cm3
Boiling Point 437.3±25.0 °C at 760 mmHg
Melting Point 175-185 °C
Molecular Formula C7H4BrN3O2
Molecular Weight 242.030
Flash Point 218.3±23.2 °C
Exact Mass 240.948685
PSA 74.50000
LogP 2.52
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.764
Storage condition 2-8°C
Water Solubility ethanol: 25 mg/mL
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H360
Precautionary Statements P201-P308 + P313
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases 60
Safety Phrases S53-S22-S36/37/39-S45
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2933990090

~90%

74209-34-0 structure

74209-34-0

Literature: Bouissane, Latifa; El Kazzouli, Said; Leger, Jean-Michel; Jarry, Christian; Rakib, El Mostapha; Khouili, Mostafa; Guillaumet, Gerald Tetrahedron, 2005 , vol. 61, # 34 p. 8218 - 8225

~0%

74209-34-0 structure

74209-34-0

Literature: Rakib; Benchidmi; Essassi; El Bouadili; Ibn Mansour; Bellan; Lopez; Lamande Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 5 p. 339 - 345

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74209-34-0 structure

74209-34-0

Literature: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 5 p. 339 - 345

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74209-34-0 structure

74209-34-0

Literature: Justus Liebigs Annalen der Chemie, , vol. 451, p. 285,302

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74209-34-0 structure

74209-34-0

Literature: Justus Liebigs Annalen der Chemie, , vol. 451, p. 285,302

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74209-34-0 structure

74209-34-0

Literature: Justus Liebigs Annalen der Chemie, , vol. 451, p. 285,302
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%