1218-98-0
1218-98-0 structure
- Name: 7,8-Dihydroneopterin
- Chemical Name: 7,8-dihydroneopterin
- CAS Number: 1218-98-0
- Molecular Formula: C9H13N5O4
- Molecular Weight: 255.23100
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-06-28 16:45:25
- Modify Date: 2024-01-10 13:02:55
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7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].
| Name | 7,8-dihydroneopterin |
|---|---|
| Synonyms |
2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine
2-amino-6-(1,2,3-trihydroxy-propyl)-7,8-dihydro-3H-pteridin-4-one 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-7,8-dihydro-1H-pteridin-4-one 2-amino-4-hydroxy-6-(D-erythro)-trihydroxypropyldihydropteridin 7,8-dihydroeopterin 7,8-dihydro-D-neopterin dihydro-7,8-D-neopterine Neopterin,7,8-dihydro 2-Amino-4-hydroxy-6-<D-erythro-1'.2'.3'-trihydroxy-propyl>-pteridin-10-C14 2-Amino-7,8-dihydro-6-(1,2,3-trihydroxypropyl)-4(1H)-pteridinone MFCD00049358 7,8-Dihydroneopterin Dihydroneopterin |
| Description | 7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1]. |
|---|---|
| Related Catalog | |
| Target |
Apoptosis; iNOS[1] |
| In Vitro | 7,8-Dihydroneopterin is a heterocyclic pteridine which produced and secreted by monocytes/macrophages upon stimulation with the cytokine interferon-y (IFN-y)[1]. 7,8-Dihydroneopterin (0.1, 0.5, 1, 2.5, 5 mM; 2 days and 5 days) inhibits growth of U373MG astroeytes[1] . Cell Viability Assay[1] Cell Line: Astrocytic cell line U373MG Concentration: 0.1, 0.5, 1, 2.5, 5 mM Incubation Time: 2 days and 5 days Result: After 2 days of treatment, a significantly lower cell number was observed for those cells treated with 5 mM and 2.5 mM. After incubation for 5 days concentrations of 1-5 mM completely abrogated acid phosphatase activity to background level found for complete cell culture medium. A significant cell growth inhibition was also visible for the cells incubated with 0.5 mM, whereas 0.1 mM did not alter cell growth. |
| References |
| Density | 2.03g/cm3 |
|---|---|
| Boiling Point | 614.6ºC at 760mmHg |
| Molecular Formula | C9H13N5O4 |
| Molecular Weight | 255.23100 |
| Flash Point | 325.5ºC |
| Exact Mass | 255.09700 |
| PSA | 156.85000 |
| Vapour Pressure | 1.13E-17mmHg at 25°C |
| Index of Refraction | 1.86 |
|
~49%
1218-98-0 |
| Literature: Antoulas, Simeon; Viscontini, Max Helvetica Chimica Acta, 1981 , vol. 64, # 4 p. 1134 - 1139 |
