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173075-45-1

173075-45-1 structure
173075-45-1 structure
  • Name: (24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid
  • Chemical Name: ganoderic acid dm
  • CAS Number: 173075-45-1
  • Molecular Formula: C30H44O4
  • Molecular Weight: 468.668
  • Catalog: Natural product Moss
  • Create Date: 2018-06-23 19:14:41
  • Modify Date: 2025-08-25 21:40:36
  • Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].
Name ganoderic acid dm
Synonyms Gaderic acid DM
Lanosta-8,24-dien-26-oic acid, 3,7-dioxo-, (24E)-
(24E)-3,7-Dioxolanosta-8,24-dien-26-oic acid
Description Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis[1][2].
Related Catalog
In Vitro Ganoderic acid DM (GADM) effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which was much stronger than that of MDA-MB-231 breast cancer cells[1]. Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1). Ganoderic acid DM markedly suppressed the expression of cathepsin K and TRAP mRNA[2]. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity[3]. Cell Viability Assay[1] Cell Line: MCF-7 and MDA-MB-231 cells. Concentration: 0-100 μM. Incubation Time: 48 h. Result: Decreased the cell viability in breast cancer cells. Cell Viability Assay[2] Cell Line: RAW-D cells. Concentration: 0-100 μg/mL. Incubation Time: 0-100 μg/mL. Result: Clearly suppressed osteoclastogenesis from the RAW 264 cell D-clone.
References

[1]. Guo-Sheng Wu, et al. Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia. 2012 Mar;83(2):408-14.

[2]. Ichiko Miyamoto, et al. Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum. Eur J Pharmacol. 2009 Jan 5;602(1):1-7.

[3]. Junbo Xia, et al. Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity. Chem Biol Interact. 2020 Jan 25;316:108932.
Density 1.1±0.1 g/cm3
Boiling Point 602.1±55.0 °C at 760 mmHg
Molecular Formula C30H44O4
Molecular Weight 468.668
Flash Point 332.0±28.0 °C
Exact Mass 468.323975
PSA 71.44000
LogP 6.90
Vapour Pressure 0.0±3.7 mmHg at 25°C
Index of Refraction 1.547
Hazard Codes Xi
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