2284-31-3
2284-31-3 structure
- Name: Pratensein
- Chemical Name: pratensein
- CAS Number: 2284-31-3
- Molecular Formula: C16H12O6
- Molecular Weight: 300.26300
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-03-24 08:00:00
- Modify Date: 2024-01-05 11:44:15
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Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1].
| Name | pratensein |
|---|---|
| Synonyms |
5,7,3'-trihydroxy-4'-methoxyisoflavone
5,7-dihydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one 3',5,7-trihydroxy-4'-methoxyisoflavone Pratensein 5,7,5'-trihydroxy-4'-methoxyisoflavone 3'-hydroxy-biochanin A |
| Description | Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)[1]. Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease[1]. Animal Model: Male 10-week old Wistar rats[1] Dosage: 20 mg/kg Administration: P.o.; once daily for 3 weeks Result: The spatial learning and memory ability of rats was improved. |
| References |
| Density | 1.512g/cm3 |
|---|---|
| Boiling Point | 576.7ºC at 760mmHg |
| Melting Point | 271-273 °C |
| Molecular Formula | C16H12O6 |
| Molecular Weight | 300.26300 |
| Flash Point | 220.3ºC |
| Exact Mass | 300.06300 |
| PSA | 100.13000 |
| LogP | 2.58540 |
| Vapour Pressure | 6.73E-14mmHg at 25°C |
| Index of Refraction | 1.697 |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2914509090 |
|
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2284-31-3 |
| Literature: Jain, A. C.; Bambah, P. K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 488 - 490 |
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2284-31-3 |
| Literature: Jain, A. C.; Bambah, P. K. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 488 - 490 |
| Precursor 3 | |
|---|---|
| DownStream 0 | |
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |