261717-18-4

261717-18-4 structure

Name: 3-(3-hydroxypropyl)-8-[(E)-2-(3-methoxyphenyl)ethenyl]-7-methyl-1-prop-2-ynylpurine-2,6-dione
Chemical Name: 3-(3-hydroxypropyl)-8-[(E)-2-(3-methoxyphenyl)ethenyl]-7-methyl-1-prop-2-ynylpurine-2,6-dione
CAS Number: 261717-18-4
Molecular Formula: C₂₁H₂₂N₄O₄
Molecular Weight: 394.42400
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-06-11 22:24:55
Modify Date: 2024-02-01 14:44:50
MSX-2 is A2A adenosine receptor antagonist, with Ki of 5 nM in human that plays an important role in Parkinson's disease[1][2].

Name	3-(3-hydroxypropyl)-8-[(E)-2-(3-methoxyphenyl)ethenyl]-7-methyl-1-prop-2-ynylpurine-2,6-dione
Synonyms	(E)-3-(3-hydroxypropyl)-8-[2-(3-methoxyphenyl)vinyl]-7-methyl-1-prop-2-ynyl-3,7-dihydropurine-2,6-dione MSX-2 3-(3-hdyroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine 3-(3-Hydroxypropyl)-8-(m-methoxystyryl)-7-methyl-1-propargylxanthine

Description	MSX-2 is A2A adenosine receptor antagonist, with Ki of 5 nM in human that plays an important role in Parkinson's disease[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
References	[1]. Manuel de Lera Ruiz, et al. Adenosine A2A Receptor as a Drug Discovery Target. J Med Chem. 2014 May 8;57(9):3623-50. [2]. Tina Becic, et al. Growth factors FGF8 and FGF2 and their receptor FGFR1, transcriptional factors Msx-1 and MSX-2, and apoptotic factors p19 and RIP5 participate in the early human limb development. Acta Histochem. 2018 Apr;120(3):205-214.

Molecular Formula	C₂₁H₂₂N₄O₄
Molecular Weight	394.42400
Exact Mass	394.16400
PSA	91.28000
LogP	1.09130

702697-16-3

~92%

261717-18-4

Literature: Hockemeyer, Joerg; Burbiel, Joachim C.; Mueller, Christa E. Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3308 - 3318

261705-81-1

261717-18-4

Literature: Hockemeyer, Joerg; Burbiel, Joachim C.; Mueller, Christa E. Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3308 - 3318

261705-85-5

261717-18-4

Literature: Hockemeyer, Joerg; Burbiel, Joachim C.; Mueller, Christa E. Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3308 - 3318

138895-22-4

261717-18-4

Literature: Hockemeyer, Joerg; Burbiel, Joachim C.; Mueller, Christa E. Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3308 - 3318

6099-04-3

261717-18-4

Literature: Sauer, Roland; Maurinsh, Juris; Reith, Ulrike; Fuelle, Friederike; Klotz, Karl-Norbert; Mueller, Christa E. Journal of Medicinal Chemistry, 2000 , vol. 43, # 3 p. 440 - 448

702697-20-9

261717-18-4

Literature: Hockemeyer, Joerg; Burbiel, Joachim C.; Mueller, Christa E. Journal of Organic Chemistry, 2004 , vol. 69, # 10 p. 3308 - 3318

261705-90-2

74-88-4

~93%

261717-18-4

Literature: Sauer, Roland; Maurinsh, Juris; Reith, Ulrike; Fuelle, Friederike; Klotz, Karl-Norbert; Mueller, Christa E. Journal of Medicinal Chemistry, 2000 , vol. 43, # 3 p. 440 - 448

Precursor 4
74-88-4 702697-16-3 138895-22-4 6099-04-3
DownStream 0

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4