Name | 3,4-Diaminopyridine |
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Synonyms |
3-Pyridinamine, 1,4-dihydro-4-imino-
3,4-Pyridinedramine 3,4-DIAMINOPYRIDINE FOR SYNTHESIS 3,4-Diaminopyridin 3,4-DAP 3,4-diamino-pyridine 3,4-diamino-pyridin 3,4-Diaminopyridine Amifampridine 3 4-DIAMINOPYRIDINE Pyridine-3,4-diamine pyridin-3,4-diaMine 4,5-diaminopyridine 3,4DIAMINOPYRIDINE EINECS 200-220-9 3,4 DI AMINO PYRIDINE Pyridin-3,4-diamin 3-amino-4-pyridinylamine MFCD00006401 3,4-Pyridinediamine diamino-3,4pyridine |
Description | Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases.Target: OthersAmifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. Amifampridine works by blocking potassium channel efflux in nerve terminals so that action potential duration is increased. Ca2+ channels can then be open for a longer time and allow greater acetylcholine release to stimulate muscle at the end plate. A 2005 systematic review from the Cochrane Collaboration found some data favouring its use in LEMS. Amifampridine is also used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. From Wikipedia. |
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Related Catalog | |
References |
[1]. http://en.wikipedia.org/wiki/3,4-Diaminopyridine#cite_note-4 |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 369.3±22.0 °C at 760 mmHg |
Melting Point | 216-218 °C(lit.) |
Molecular Formula | C5H7N3 |
Molecular Weight | 109.129 |
Flash Point | 204.9±9.5 °C |
Exact Mass | 109.063995 |
PSA | 64.93000 |
LogP | -0.09 |
Vapour Pressure | 0.0±0.8 mmHg at 25°C |
Index of Refraction | 1.676 |
Water Solubility | 24 g/L (20 ºC) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H300 + H330-H311-H315-H319-H335 |
Precautionary Statements | P260-P264-P280-P284-P301 + P310-P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | T:Toxic |
Risk Phrases | R25;R36/37/38 |
Safety Phrases | S26-S28-S36/37/39-S45-S37/39-S28A |
RIDADR | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS | US7600000 |
Packaging Group | I |
Hazard Class | 6.1 |
HS Code | 29333999 |
~99% 54-96-6 |
Literature: Bakke; Riha Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 5 p. 1143 - 1145 |
~96% 54-96-6 |
Literature: Campbell; Greene; Lavagnino; et al. Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 669 - 672 |
~76% 54-96-6 |
Literature: Campbell; Greene; Lavagnino; et al. Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 669 - 672 |
~% 54-96-6 |
Literature: Journal of Heterocyclic Chemistry, , vol. 23, # 3 p. 669 - 672 |
~% 54-96-6 |
Literature: Journal of Heterocyclic Chemistry, , vol. 23, # 3 p. 669 - 672 |
~% 54-96-6 |
Literature: Journal of Heterocyclic Chemistry, , vol. 23, # 3 p. 669 - 672 |
~% 54-96-6 |
Literature: Journal of Heterocyclic Chemistry, , vol. 36, # 5 p. 1143 - 1145 |
~% 54-96-6 |
Literature: Journal of Heterocyclic Chemistry, , vol. 36, # 5 p. 1143 - 1145 |
~% 54-96-6 |
Literature: Journal of Heterocyclic Chemistry, , vol. 36, # 5 p. 1143 - 1145 |
Precursor 9 | |
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DownStream 10 | |
HS Code | 2933399090 |
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Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |