139652-86-1
139652-86-1 structure
- Name: 6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl
- Chemical Name: 6-[6-(4-hydroxypiperidin-1-yl)hexoxy]-3-methyl-2-phenylchromen-4-one,hydrochloride
- CAS Number: 139652-86-1
- Molecular Formula: C27H34ClNO4
- Molecular Weight: 472.01600
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2016-02-27 05:20:25
- Modify Date: 2024-01-07 17:55:48
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Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor[1].
| Name | 6-[6-(4-hydroxypiperidin-1-yl)hexoxy]-3-methyl-2-phenylchromen-4-one,hydrochloride |
|---|---|
| Synonyms |
6-[6-(4-Hydroxypiperidinyl)hexoxy]-3-methyl-2-phenyl-4H-1-benzopyran-4-one hydrochloride
6-(6-(4-Hydroxypiperidinyl)hexyloxy)-3-methylflavone HCl 4H-1-Benzopyran-4-one,6-((6-(4-hydroxy-1-piperidinyl)hexyl)oxy)-3-methyl-2-phenyl-,hydrochloride 6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone hydrochloride |
| Description | Sigma-LIGAND-1 hydrochloride is a selective sigma receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively. Sigma-LIGAND-1 hydrochloride has a Ki of 4000 nM at the dopamine D2 receptor[1]. |
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| Related Catalog | |
| Target |
IC50: 16 nM (DTG site of sigma receptor), 19 nM (PPP site of sigma receptor)[1] Ki: 4000 nM (Dopamine D2 receptor)[1] |
| In Vivo | Administration of Sigma-LIGAND-1 hydrochloride reverseS amphetamine-induced hyperlocomotion in mice, a behavioral model sensitive to antipsychotic compounds. Sigma-LIGAND-1 hydrochloride and its structural analogues have the potential antipsychotic activity[1]. |
| References |
| Boiling Point | 615.5ºC at 760 mmHg |
|---|---|
| Molecular Formula | C27H34ClNO4 |
| Molecular Weight | 472.01600 |
| Flash Point | 326.1ºC |
| Exact Mass | 471.21800 |
| PSA | 62.91000 |
| LogP | 5.90420 |
| Vapour Pressure | 5.23E-16mmHg at 25°C |