820957-38-8

820957-38-8 structure

Name: Retosiban
Chemical Name: (3R,6R)-6-[(2S)-butan-2-yl]-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxoethyl]piperazine-2,5-dione
CAS Number: 820957-38-8
Molecular Formula: C₂₇H₃₄N₄O₅
Molecular Weight: 494.58300
Catalog: Signaling Pathways GPCR/G Protein Oxytocin Receptor
Create Date: 2016-08-01 12:06:02
Modify Date: 2025-08-27 17:41:43
Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.

Name	(3R,6R)-6-[(2S)-butan-2-yl]-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2-methyl-1,3-oxazol-4-yl)-2-morpholin-4-yl-2-oxoethyl]piperazine-2,5-dione
Synonyms	UNII-GIE06H28OX Retosiban

Description	Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Oxytocin Receptor Research Areas >> Neurological Disease
Target	IC50: 0.65 nM (Oxytocin)[1]
References	[1]. Liddle J, et al. The discovery of GSK221149A: a potent and selective oxytocin antagonist. Bioorg Med Chem Lett. 2008 Jan 1;18(1):90-4.

110-91-8

820957-45-7

820957-38-8

Literature: GLAXO GROUP LIMITED Patent: WO2005/840 A1, 2005 ; Location in patent: Page/Page column 12-13 ; WO 2005/000840 A1

110-91-8

554448-74-7

167223-42-9

86652-64-4

113732-84-6

Detail

Literature: GLAXO GROUP LIMITED Patent: WO2005/840 A1, 2005 ; Location in patent: Page/Page column 13-15 ; WO 2005/000840 A1

Precursor 4
110-91-8 820957-45-7 86652-64-4 113732-84-6
DownStream 0