DC Chemicals Limited
China
Product Name: Wnt-C59
Price: $450.0/100mg $900.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

1243243-89-1

1243243-89-1 structure

1243243-89-1 structure

Name: Wnt-C59
Chemical Name: 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide
CAS Number: 1243243-89-1
Molecular Formula: C₂₅H₂₁N₃O
Molecular Weight: 379.454
Catalog: Biochemical Inhibitor Stem Cells & Wnt Signaling Paths (Stem Cells & Wnt) Wnt/beta-catenin inhibitor
Create Date: 2018-12-29 22:27:49
Modify Date: 2024-01-07 09:28:54
Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.

Name	2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide
Synonyms	2-[4-(2-Methyl-4-pyridinyl)phenyl]-N-[4-(3-pyridinyl)phenyl]acetamide S7037,C59 QC-8389 CS-1420 Benzeneacetamide, 4-(2-methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]- Wnt-C59 2-[4-(2-methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide Wnt-C59 (C59)

Description	Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Porcupine Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Cancer
Target	IC50: 74 pM (PORCN)[1]
In Vitro	Wnt-C59 (C59) inhibits PORCN activity in vitro at nanomolar concentrations, as assessed by inhibition of Wnt palmitoylation, Wnt interaction with the carrier protein Wntless/WLS, Wnt secretion, and Wnt activation of β-catenin reporter activity. Wnt-C59 inhibits WNT3A-mediated activation of a multimerized TCF-binding site driving luciferase with an IC50 of 74 pM[1].
In Vivo	Wnt-C59 displays good bioavailability in mice. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice while downregulating Wnt/β-catenin target genes[1]. Wnt-C59 has the potential to eradicate cancer stem cells in human tumors. Wnt-C59 inhibits stemness properties of NPC cells in a dosage-dependent manner by arresting sphere formation in both HNE1 and SUNE1 cells[2].
Cell Assay	1×104 HK1, CNE1, HNE1 and SUNE1 cells are seeded in 24-well plates, and Wnt-C59 (5 μM, 10 μM, and 20 μM) is added the next day. Cell confluence is determined by microscopy at 24, 48, 72, and 96 hours after seeding of cells. The IC50 is determined by MTT assay[2].
Animal Admin	Mice[1] Female nude mice orthotopically transplanted with independent MMTV-WNT1 tumors are treated with vehicle or Wnt-C59 10 mg/kg once daily for 17 days. Tumor volumes are measured on alternate days[1].
References	[1]. Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73(2):502-7. [2]. Cheng Y, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6(16):14428-39.

Density	1.2±0.1 g/cm3
Boiling Point	628.3±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₂₁N₃O
Molecular Weight	379.454
Flash Point	333.8±31.5 °C
Exact Mass	379.168457
PSA	54.88000
LogP	4.19
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.648
Storage condition	-20°C

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%