175724-30-8
175724-30-8 structure
- Name: Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane
- Chemical Name: Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
- CAS Number: 175724-30-8
- Molecular Formula: C25H47NO9
- Molecular Weight: 505.64200
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2016-12-27 23:03:22
- Modify Date: 2025-08-25 16:39:46
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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine |
|---|---|
| Synonyms | tert-butyl 3-[2-amino-3-[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]-2-[[3-[(2-methylpropan-2-yl)oxy]-3-oxopropoxy]methyl]propoxy]propanoate |
| Description | Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C25H47NO9 |
|---|---|
| Molecular Weight | 505.64200 |
| Exact Mass | 505.32500 |
| PSA | 132.61000 |
| LogP | 3.62940 |