71112-91-9

71112-91-9 structure

Name: 1-bromo-2-(2-bromophenyl)disulfanyl-benzene
Chemical Name: 1-bromo-2-[(2-bromophenyl)disulfanyl]benzene
CAS Number: 71112-91-9
Molecular Formula: C₁₂H₈Br₂S₂
Molecular Weight: 376.13000
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2017-05-21 11:42:41
Modify Date: 2024-01-16 17:25:39
Tubulin inhibitor 28 (compound 2g) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 28 shows anti-proliferative activity for MCF-7 cells[1].

Name	1-bromo-2-[(2-bromophenyl)disulfanyl]benzene
Synonyms	1,1'-disulfanediylbis(2-bromobenzene) di-o-bromophenyl disulfide 1,2-bis(2-bromophenyl)disulfane bis(2-bromophenyl) disulfide 1,2-bis(2-bromophenyl) disulfide di-(2-bromophenyl)disulfide 2-bromophenyl disulfide

Description	Tubulin inhibitor 28 (compound 2g) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 28 shows anti-proliferative activity for MCF-7 cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	IC50: 1.2 µM (tubulin)[1].
In Vitro	Tubulin inhibitor 28 (compound 2g) shows anti-proliferative activity with an IC50 value of >10 µM for MCF-7 cells[1].
References	[1]. Khodyuk RGD, et al. Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity. Bioorg Chem. 2020 Aug;101:104017.

6320-02-1

~96%

71112-91-9

Literature: Abaee, M. Saeed; Mojtahedi, Mohammad M.; Navidipoor, Somayeh Synthetic Communications, 2011 , vol. 41, # 2 p. 170 - 176

104967-26-2

71112-91-9

Literature: Sindelar; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1484 - 1497

104967-30-8

71112-91-9

Literature: Sindelar; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1484 - 1497

104967-32-0

71112-91-9

Literature: Sindelar; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1484 - 1497

104967-23-9

71112-91-9

Literature: Sindelar; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 7 p. 1484 - 1497