Zhejiang Hangyu API Co., Ltd
China
Product Name: Dapoxetine
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Dapoxetin
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

119356-77-3

119356-77-3 structure

119356-77-3 structure

Name: Dapoxetine
Chemical Name: Dapoxetine
CAS Number: 119356-77-3
Molecular Formula: C₂₁H₂₃NO
Molecular Weight: 305.413
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-08-24 16:59:02
Modify Date: 2024-01-02 19:46:30
Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1].

Name	Dapoxetine
Synonyms	(1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine Benzenemethanamine, N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-, (αS)- Priligy Dapoxetina (1S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine Dapoxetine (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine (+)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine (S)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine (1s)-n,n-dimethyl-3-(1-naphthyloxy)-1-phenylpropan-1-amine MFCD00865355 (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine Dapoxetinum

Description	Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
In Vitro	Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine. Dapoxetine inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1]
In Vivo	Dapoxetine (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats[2]. Animal Model: Adult male Wistar rats[2] Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg Administration: Oral gavage; 1-10 mg/kg; once daily Result: Reverted most of the changes made by testosterone injection.
References	[1]. Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89. [2]. Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60.

Density	1.1±0.1 g/cm3
Boiling Point	454.4±38.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₃NO
Molecular Weight	305.413
Flash Point	132.6±29.1 °C
Exact Mass	305.177979
PSA	12.47000
LogP	5.13
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.607
Storage condition	2-8°C

HS Code	2922199090

HS Code	2922299090
Summary	2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%