115074-43-6

115074-43-6 structure

Name: Mupirocin calcium hydrate
Chemical Name: mupirocin calcium, reference spectrum ep standard
CAS Number: 115074-43-6
Molecular Formula: C₂₆H₄₄O_9.1/₂Ca_.H₂O
Molecular Weight: 1075.34000
Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
Create Date: 2018-03-29 08:00:00
Modify Date: 2025-08-20 19:51:27
Mupirocin calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2].

Name	mupirocin calcium, reference spectrum ep standard
Synonyms	Mupirocin calcium dihydrate Unii-rg38I2p540 MupirocinCalcium mupirocin calcium hydrate Calcium mupirocin dihydrate Mupirocin Calcium Salt

Description	Mupirocin calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Mupirocin Calcium Salt shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin Calcium Salt is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum[1].
In Vivo	Mupirocin Calcium Salt is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A[1].
References	[1]. Sutherland R, et al. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother. 1985 Apr;27(4):495-8. [2]. Parenti MA, et al. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6(10):761-70.

Boiling Point	672.3ºC at 760 mmHg
Molecular Formula	C₂₆H₄₄O_9.1/₂Ca_.H₂O
Molecular Weight	1075.34000
Flash Point	216.5ºC
Exact Mass	1074.57000
PSA	288.56000
LogP	4.90220
Vapour Pressure	5.91E-21mmHg at 25°C
Storage condition	-20℃
Water Solubility	Very slightly soluble in water, sparingly soluble in anhydrous ethanol and in methylene chloride.

RIDADR	NONH for all modes of transport