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548-66-3

548-66-3 structure
548-66-3 structure
  • Name: Drofenine hydrochloride
  • Chemical Name: drofenine hydrochloride
  • CAS Number: 548-66-3
  • Molecular Formula: C20H32ClNO2
  • Molecular Weight: 353.92700
  • Catalog: analytical chemistry Standard Forensic and veterinary standards
  • Create Date: 2018-09-08 11:13:06
  • Modify Date: 2025-08-25 16:52:28
  • Drofenine hydrochloride is a potent competitive inhibitor of BChE, and the ki values of Drofenine is calculated to be 3 uM.IC50 value: 3 uM (ki)Target: BChEBenactyzine is widely used anticholinergic drugs, acts on smooth muscle to stop muscle spasms.
Name drofenine hydrochloride
Synonyms cyclovegantine
hexahydroadiphenine
cycloadiphenine
Cyclovegantin*Hydrochlorid
Cycloadiphenin*Hydrochlorid
Drofeninhydrochlorid
it-19
Cyclohexyl-phenyl-essigsaeure-(2-diaethylamino-aethylester),Hydrochlorid
DROFENINE HCL
cyclohexyl-phenyl-acetic acid-(2-diethylamino-ethyl ester),hydrochloride
trasentinh
DrofeninHCl
Description Drofenine hydrochloride is a potent competitive inhibitor of BChE, and the ki values of Drofenine is calculated to be 3 uM.IC50 value: 3 uM (ki)Target: BChEBenactyzine is widely used anticholinergic drugs, acts on smooth muscle to stop muscle spasms.
Related Catalog
References

[1]. Bodur E, et al. Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase. Arch Biochem Biophys. 2001 Feb 1;386(1):25-29.
Boiling Point 417.4ºC at 760mmHg
Melting Point 145-147°
Molecular Formula C20H32ClNO2
Molecular Weight 353.92700
Flash Point 124.6ºC
Exact Mass 353.21200
PSA 29.54000
LogP 5.03750
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GU6825000
CHEMICAL NAME :
Cyclohexaneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride
CAS REGISTRY NUMBER :
548-66-3
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C20-H31-N-O2.Cl-H
MOLECULAR WEIGHT :
353.98
WISWESSER LINE NOTATION :
L6TJ AYR&VO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 3,238,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1201 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 3,238,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 3,238,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 28,37,1965
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS GU6825000
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