50656-77-4

50656-77-4 structure

Name: Niranthin
Chemical Name: Niranthin
CAS Number: 50656-77-4
Molecular Formula: C₂₄H₃₂O₇
Molecular Weight: 432.507
Catalog: Natural product Lignans
Create Date: 2017-04-05 00:06:41
Modify Date: 2024-01-11 19:36:19
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis treatment[1].

Name	Niranthin
Synonyms	1,3-Benzodioxole, 6-[(2R,3R)-4-(3,4-dimethoxyphenyl)-2,3-bis(methoxymethyl)butyl]-4-methoxy- 6-[(2R,3R)-3-(3,4-Dimethoxybenzyl)-4-methoxy-2-(methoxymethyl)butyl]-4-methoxy-1,3-benzodioxole

Description	Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis treatment[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Research Areas >> Inflammation/Immunology
Target	Topoisomerase
References	[1]. Sayan Chowdhury, et al. The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice. EMBO Mol Med. 2012 Oct;4(10):1126-43.

Hazard Codes	Xi