l-3-hydroxy-n-methylmorphinan dihydrate
Names
[ CAS No. ]:
5985-38-6
[ Name ]:
l-3-hydroxy-n-methylmorphinan dihydrate
[Synonym ]:
LEVORPHANOL TARTRATE SALT
LEVORPHANOL TARTRATE
levorphanol tartrate dihydrate
LEVORPHANOLTARTRATE,USP
levorphanol tartrate methanol solution
L-3-HYDROXY-N-METHYLMORPHINAN
Chemical & Physical Properties
[ Boiling Point ]:
410.4ºC at 760 mmHg
[ Molecular Formula ]:
C21H33NO9
[ Molecular Weight ]:
443.48800
[ Flash Point ]:
11ºC
[ Exact Mass ]:
443.21600
[ PSA ]:
156.99000
[ LogP ]:
0.76710
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD1924200
- CAS REGISTRY NUMBER :
- 5985-38-6
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C17-H23-N-O.C4-H6-O6.2H2-O
- MOLECULAR WEIGHT :
- 443.55
- WISWESSER LINE NOTATION :
- T6 G665/FP 2AF P FX ONT&TTJ IQ O1 &QVYQYQVQ &QH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 23 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 85,387,1951
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H312 + H332-H317-H334-H360
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P201-P261-P280-P284-P308 + P313
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T,F
[ Risk Phrases ]:
R61
[ Safety Phrases ]:
53-22-36/37-45-16-7
[ RIDADR ]:
UN 1544 6.1/PG 3
[ RTECS ]:
QD1924200
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
J. Pharmacol. Exp. Ther. 289 , 965, (1999)
Effects of low (butorphanol, nalbuphine)-, intermediate (buprenorphine)-, and high (morphine, levorphanol)-efficacy mu opioids were examined in F344, Sprague-Dawley (SD), Long-Evans (LE), and Lewis ra...
Characterization and distribution of a cloned rat mu-opioid receptor.J. Neurochem. 64 , 14-24, (1995)
We have cloned and expressed a rat brain cDNA, TS11, that encodes a mu-opioid receptor based on pharmacological, physiological, and anatomical criteria. Membranes were prepared from COS-7 cells transi...