GSK-3β inhibitor 11

Names

[ CAS No. ]:
536731-65-4

[ Name ]:
GSK-3β inhibitor 11

[Synonym ]:
2H-Isoindole-2-acetamide, 1,3-dihydro-N-[4-(3-methoxyphenyl)-2-thiazolyl]-1,3-dioxo-
2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]acetamide

Biological Activity

[Description]:

GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM). GSK-3β inhibitor 11 can be used in neurodegenerative disease research[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Neurological Disease
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3β:10.02 μM (IC50)


[References]

[1]. Fu G, et al. Pharmacophore Modeling, Ensemble Docking, Virtual Screening, and Biological Evaluation on Glycogen Synthase Kinase-3β. Mol Inform. 2014 Sep;33(9):610-26.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C20H15N3O4S

[ Molecular Weight ]:
393.416

[ Exact Mass ]:
393.078339

[ LogP ]:
3.76

[ Index of Refraction ]:
1.686

[ Storage condition ]:
-20°C

Related Compounds