LRRK2/NUAK1/TYK2-IN-1

Names

[ CAS No. ]:
2629192-96-5

[ Name ]:
LRRK2/NUAK1/TYK2-IN-1

Biological Activity

[Description]:

LRRK2/NUAK1/TYK2-IN-1 (conpound 226) shows inhibitory activity toward LRRK2 (Wt), LRRK2 (G2019), TYK2 and NUAK1, with IC50 values lower than 10 nM. LRRK2/NUAK1/TYK2-IN-1 can be used for autoimmune disease research[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> Autophagy >> LRRK2
Research Areas >> Inflammation/Immunology
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK

[Target]

Tyk2

NUAK1


[References]

[1]. Roland Koestler, et al. 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease. Patent WO2021048618A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H11F3N6

[ Molecular Weight ]:
392.34

Related Compounds