Tubulin polymerization-IN-31

Names

[ CAS No. ]:
2421121-79-9

[ Name ]:
Tubulin polymerization-IN-31

Biological Activity

[Description]:

Tubulin polymerization-IN-31 (Compound 4c) is a tubulin polymerization inhibitor with an IC50 of 3.64 μM. Tubulin polymerization-IN-31 induces cancer cell apoptosis and shows antitumor activity[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

IC50: 3.64 μM (Tubulin polymerization)[1]


[In Vitro]

Tubulin polymerization-IN-31 (Compound 4c) shows antitumor activities with IC50 values of 6.02 ± 0.5, 8.45 ± 1.0 and 6.28 ± 0.6 μM against HepG2, HCT-116 and MCF-7, respectively[1].

[References]

[1]. Shaheen MA, et al. 1,4,5,6,7,8-Hexahydroquinolines and 5,6,7,8-tetrahydronaphthalenes: A new class of antitumor agents targeting the colchicine binding site of tubulin. Bioorg Chem. 2020 Jun;99:103831.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H13ClFN3

[ Molecular Weight ]:
325.77

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.