2421121-79-9

2421121-79-9 structure

Name: Tubulin polymerization-IN-31
Chemical Name: Tubulin polymerization-IN-31
CAS Number: 2421121-79-9
Molecular Formula: C₁₈H₁₃ClFN₃
Molecular Weight: 325.77
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-11-07 18:29:28
Modify Date: 2025-09-26 16:25:02
Tubulin polymerization-IN-31 (Compound 4c) is a tubulin polymerization inhibitor with an IC50 of 3.64 μM. Tubulin polymerization-IN-31 induces cancer cell apoptosis and shows antitumor activity[1].

Name	Tubulin polymerization-IN-31

Description	Tubulin polymerization-IN-31 (Compound 4c) is a tubulin polymerization inhibitor with an IC50 of 3.64 μM. Tubulin polymerization-IN-31 induces cancer cell apoptosis and shows antitumor activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	IC50: 3.64 μM (Tubulin polymerization)[1]
In Vitro	Tubulin polymerization-IN-31 (Compound 4c) shows antitumor activities with IC50 values of 6.02 ± 0.5, 8.45 ± 1.0 and 6.28 ± 0.6 μM against HepG2, HCT-116 and MCF-7, respectively[1].
References	[1]. Shaheen MA, et al. 1,4,5,6,7,8-Hexahydroquinolines and 5,6,7,8-tetrahydronaphthalenes: A new class of antitumor agents targeting the colchicine binding site of tubulin. Bioorg Chem. 2020 Jun;99:103831.

Molecular Formula	C₁₈H₁₃ClFN₃
Molecular Weight	325.77