APG-2449

Names

[ CAS No. ]:
2196186-84-0

[ Name ]:
APG-2449

Biological Activity

[Description]:

APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ALK

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK

[References]

[1]. Fang DD, et al. Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models. BMC Cancer. 2022 Jul 11;22(1):752.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₄₂ClN₅O₄S

[ Molecular Weight ]:
640.24

Related Compounds

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