7-Cyano-7-deaza-2'-deoxy guanosine

Names

[ CAS No. ]:
199859-58-0

[ Name ]:
7-Cyano-7-deaza-2'-deoxy guanosine

[Synonym ]:
3H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 2-amino-7-(2-deoxy-α-D-erythro-pentofuranosyl)-4,7-dihydro-4-oxo-
2-Amino-7-(2-deoxy-α-D-erythro-pentofuranosyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Biological Activity

[Description]:

7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Molecular Formula ]:
C12H13N5O4

[ Molecular Weight ]:
291.263

[ Exact Mass ]:
291.096741

[ LogP ]:
-1.91

[ Index of Refraction ]:
1.849

Related Compounds