MT-3014

Names

[ CAS No. ]:
1332727-40-8

[ Name ]:
MT-3014

Biological Activity

[Description]:

MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Neurological Disease

[Target]

human PDE 10A:0.062 nM (IC50)

bovine PDE 10A:0.09 nM (IC50)


[References]

[1]. Koizumi Y, et al. Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety. Bioorg Med Chem. 2019 Jun 19.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H25F2N7O

[ Molecular Weight ]:
453.49

Related Compounds