B-Raf IN 8

Names

[ CAS No. ]:
1215313-19-1

[ Name ]:
B-Raf IN 8

Biological Activity

[Description]:

B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC50 values of 9.78, 13.78, 18.52 and 29.85 µM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

B-Raf:70.65 ± 0. nM (IC50)


[References]

[1]. Thabit MG, et al. Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity. Bioorg Chem. 2020 Oct;103:104148.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H17N3O2

[ Molecular Weight ]:
307.35

Related Compounds