G-{d-Arg}-GDSP

G-{d-Arg}-GDSP is an RGD peptide analogue that binds to the adhesion receptor of integrins and inhibits cellular fibronectin attachment as well as osteoclast resorption[1].

Research Areas >> Others

Signaling Pathways >> Others >> Others

G-{d-Arg}-GDSP (17-850 μM, 10 days) significantly inhibits osteoclastic resorption at 170 μM in 17-day-old fetal mouse metacarpals and inhibits 45Ca release in osteoclast precursor-dependent bone organ culture[1]. G-{d-Arg}-GDSP (170 μM, 4 days) shows inhibition of anchorage of periosteal TRAP+ precursors to the mineralized matrix and subsequent osteoclast formation compared with the control group[1].