2'-Azido-2'-deoxyuridine

Names

[ Name ]:
2'-Azido-2'-deoxyuridine

[Synonym ]:
2'-Azido-2'-deoxyuridine

Biological Activity

[Description]:

2'-Azido-2'-deoxyuridine (N3dUrd) is a ribonucleotide reductase inhibitor. 2'-Azido-2'-deoxyuridine has anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[In Vitro]

2'-Azido-2'-deoxyuridine (N3dUrd) has IC50s of >350 μM for ribonucleotide reductase activity in chinese hamster ovary (CHO) and 3T6 cell[1].

[References]

[1]. Kang SH, et al. Biological activity and phosphorylation of 2_'-azido-2_'-deoxyuridine and 2_'-azido-2_'-deoxycytidine. Nucleosides Nucleotides. 1998 Jun;17(6):1077-88.

Chemical & Physical Properties

[ Melting Point ]:
149-153ºC

[ Molecular Formula ]:
C₉H₁₁N₅O₅

[ Molecular Weight ]:
269.214

[ Exact Mass ]:
269.076019

[ PSA ]:
154.30000

[ LogP ]:
-1.10

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

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