Calcitonin Gene Related Peptide Fragment 8-37 human

Names

[ CAS No. ]:
119911-68-1

[ Name ]:
Calcitonin Gene Related Peptide Fragment 8-37 human

[Synonym ]:
FBHuman
CGRP-I 8-37
EINECS 232-693-2
CGRP-I 8-37,HUMAN
MFCD00133153
VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2
ALA-CYS-ASN-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-ASP-PHE-LEU-SER-ARG-SER-GLY-GLY-VAL-GLY-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACNTATCVTHRLADFLSRSGGVGKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE
CYS2-CYS7
HCGRP-(8-37)

Biological Activity

[Description]:

HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor. Sequence: Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CGRP Receptor

Signaling Pathways >> Neuronal Signaling >> CGRP Receptor

Peptides

Research Areas >> Cardiovascular Disease

Research Areas >> Metabolic Disease

[Target]

CGRP receptor[1]

[References]

[1]. Chiba T, et al. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am J Physiol. 1989 Feb;256(2 Pt 1):E331-5.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.46±0.1 g/cm3

[ Molecular Formula ]:
C₁₃₉H₂₃₀N₄₄O₃₈

[ Molecular Weight ]:
3125.59000

[ Exact Mass ]:
3123.74000

[ PSA ]:
1339.16000

[ LogP ]:
1.11560

[ Appearance of Characters ]:
powder

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Calcitonin gene-related peptide stimulates proliferation and osteogenic differentiation of osteoporotic rat-derived bone mesenchymal stem cells.

Mol. Cell Biochem. 402(1-2) , 101-10, (2015)

Osteoporosis, a systemic bone disorder, is prevalent in postmenopausal woman. Bone mesenchymal stem cells (BMSCs), precursors of osteogenic cells, may contribute to prevention or treatment of bone fru...

Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats.

Peptides 47 , 1-6, (2013)

Direct administration of intermedin (IMD) into the brain elicits cardiovascular effects different from the systemic administration. Nucleus tractus solitarii (NTS) is an important region for the cardi...

Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats.

Hypertension 63(2) , 330-7, (2014)

Intermedin (IMD) is a member of calcitonin/calcitonin gene-related peptide family, which shares the receptor system consisting of calcitonin receptor-like receptor (CRLR) and receptor activity-modifyi...