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δ-Endorphin (human)

Names

[ CAS No. ]:
76622-84-9

[ Name ]:
δ-Endorphin (human)

[Synonym ]:
beta-Endorphin huMan fragMent 1-27
5-[[5-amino-1-[[2-[[4-amino-1-[[1-[2-[[1-[[1-[[1-[[1-[[2-[[5-amino-1-[[3-amino-1-[[2-[[1-[[1-[[5-amino-1-[[3-amino-1-[[2-[[1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]pentyl]carbamoyl]-2-methyl-butyl]carbamoyl]-2-methyl-butyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]pentyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]pyrrolidine-1-carbonyl]-2-hydroxy-propyl]carbamoyl]-4-oxo-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]pentyl]amino]-4-[[2-[[2-[[2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methylsulfanyl-butanoyl]amino]-3-hydroxy-butanoyl]amino]-3-hydroxy-propanoyl]amino]-5-oxo-pentanoic acid

Biological Activity

[Description]:

β-Endorphin (1-27) (human) is an opioid antagonist that binds μ-, δ-, and κ-opioid receptors with Kis of 5.31, 6.17, and 39.82 nM, respectively. β-Endorphin (1-27) (human) inhibits β-Endorphin (HY-P1502)-induced and etorphine-induced analgesia[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 5.31 nM (μ-opioid receptor), 6.17 nM (δ-opioid receptor), 39.82 nM (κ-opioid receptor)[1]


[References]

[1]. Mansour A, et al. The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores. Brain Res. 1995 Nov 27;700(1-2):89-98.  

[2]. Nicolas P, et al. Beta-endorphin-(1-27) is a naturally occurring antagonist to etorphine-induced analgesia. Proc Natl Acad Sci U S A. 1985 May;82(10):3178-81.  

Chemical & Physical Properties

[ Molecular Formula ]:
C139H217N33O40S

[ Molecular Weight ]:
3022.47

[ Exact Mass ]:
3020.57000

[ PSA ]:
1222.67000

[ LogP ]:
3.79500

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Related Compounds