H-Tyr-D-Ala-Gly-Phe-Met-NH2

Names

[ Name ]:
H-Tyr-D-Ala-Gly-Phe-Met-NH2

[Synonym ]:
DAME
[D-Ala2]Met-enkephalinamide
D-Enkephalin
Met-enkephalinamide,ala(2)
[D-Ala2-Met5]enkephalinamide
Methionine-enkephalinamide,ala(2)
Enkephalinamide-met,ala(2)
Tyr-D-Ala-Gly-Phe-Met-NH2
Dalamid
Dalamide
2-Ala-met-enkephalinamide
Enkephalinamide-met,alanine(2)
[D-Ala2]-methionine enkephalinamide
H-Tyr-D-Ala-Gly-Phe-Met-NH2
Enkephalin, Amide-[D-Ala2, Met5]

Biological Activity

[Description]:

[D-Ala2]-Met-Enkephalinamide, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism. [D-Ala2]-Met-Enkephalinamide has analgesic properties[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[In Vivo]

[D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism in Sprague-Dawley rats[1]. Animal Model: Male Sprague-Dawley rats (250-320 g)[1] Dosage: 10, 50, 100, 150, and 200 mg/kg Administration: Intracerebroventrical injection Result: Decreased in bile flow that ranged from 12% to 41%. Decreased bicarbonate secretion into bile.

Chemical & Physical Properties

[ Density]:
1.286 g/cm3

[ Boiling Point ]:
1057.4ºC at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₈N₆O₆S

[ Molecular Weight ]:
586.70300

[ Flash Point ]:
593.3ºC

[ Exact Mass ]:
586.25700

[ PSA ]:
231.04000

[ LogP ]:
2.29780

[ Index of Refraction ]:
1.601

H-Tyr-D-Ala-Gly-Phe-Met-NH2

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds