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Caspase-3/7 Inhibitor II

Names

[ CAS No. ]:
775289-20-8

[ Name ]:
Caspase-3/7 Inhibitor II

[Synonym ]:
L-Leucinamide, N-acetyl-L-α-aspartyl-L-asparaginyl-N-[(1S)-2-carboxy-1-formylethyl]-
N-Acetyl-L-α-aspartyl-L-asparaginyl-N-[(2S)-1-carboxy-3-oxo-2-propanyl]-L-leucinamide

Biological Activity

[Description]:

Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Kiapp: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Apoptosis >> Caspase
Research Areas >> Neurological Disease

[Target]

Caspase-3/7[1]


[References]

[1]. Yoshimori A, et al. Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO. BMC Pharmacol. 2007 Jun 27;7:8.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1034.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H31N5O10

[ Molecular Weight ]:
501.488

[ Flash Point ]:
579.1±34.3 °C

[ Exact Mass ]:
501.207092

[ LogP ]:
-0.50

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.536

Related Compounds