5-Iodotubercidin
Names
[ CAS No. ]:
24386-93-4
[ Name ]:
5-Iodotubercidin
[Synonym ]:
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-iodo-7-β-D-ribofuranosyl-
MFCD00055131
5-Iodo-7-(β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5-Iodotubercidin
5-Iodotubericidin
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 26 nM (adenosine kinase)
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
2.5±0.1 g/cm3
[ Boiling Point ]:
701.5±60.0 °C at 760 mmHg
[ Melting Point ]:
216-217ºC dec.
[ Molecular Formula ]:
C11H13IN4O4
[ Molecular Weight ]:
392.150
[ Flash Point ]:
378.0±32.9 °C
[ Exact Mass ]:
391.998138
[ PSA ]:
126.65000
[ LogP ]:
0.91
[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C
[ Index of Refraction ]:
1.919
[ Storage condition ]:
2-8°C
[ Stability ]:
Store tightly sealed at 4°C; Light Sensitive
[ Water Solubility ]:
0.1 M HCl: 0.7 mg/mL
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2934999090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Mol. Pharmacol. 87(1) , 39-51, (2015)
Cell-permeable orthosteric ligands can assist folding of G protein-coupled receptors in the endoplasmic reticulum (ER); this pharmacochaperoning translates into increased cell surface levels of recept...
Endothelial and Neuronal Nitric Oxide Activate Distinct Pathways on Sympathetic Neurotransmission in Rat Tail and Mesenteric Arteries.PLoS ONE 10 , e0129224, (2015)
Nitric oxide (NO) seems to contribute to vascular homeostasis regulating neurotransmission. This work aimed at assessing the influence of NO from different sources and respective intracellular pathway...
An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat.Neuropharmacology 97 , 160-70, (2015)
Adenosine kinase (AK) inhibitor is a potential candidate for controlling pain, but some AK inhibitors have problems of adverse effects such as motor impairment. ABT-702, a non-nucleoside AK inhibitor,...