Tyrphostin B42 (AG-490)
Names
[ CAS No. ]:
133550-30-8
[ Name ]:
Tyrphostin B42 (AG-490)
[Synonym ]:
N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
(E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
Tyrphostin B42
(2E)-N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide
MFCD00209833
2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-, (2E)-
AG490
AG-490
Biological Activity
[Description]:
[Related Catalog]:
[Target]
EGFR
Stat-3
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
615.2±55.0 °C at 760 mmHg
[ Melting Point ]:
215°C(lit.)
[ Molecular Formula ]:
C17H14N2O3
[ Molecular Weight ]:
294.305
[ Flash Point ]:
325.9±31.5 °C
[ Exact Mass ]:
294.100433
[ PSA ]:
93.35000
[ LogP ]:
2.11
[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C
[ Index of Refraction ]:
1.679
[ Storage condition ]:
−20°C
[ Water Solubility ]:
ethanol: 5 mg/mL
MSDS
Safety Information
[ Symbol ]:
GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H400
[ Precautionary Statements ]:
P273-P301 + P310
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36
[ RIDADR ]:
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all
[ WGK Germany ]:
1
[ RTECS ]:
UC6316197
[ Packaging Group ]:
III
[ HS Code ]:
2926909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2926909090
[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
Articles
Brain Res. 816 , 587, (1999)
We have investigated the effects of protein tyrosine kinases (PTKs) inhibitors on high-threshold voltage activating (HVA) calcium currents in CA1 pyramidal neurones, whole-cell patch-clamp recorded fr...
Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells.Leukemia 15 , 787-793, (2001)
Interleukin-2 (IL-2) is a growth factor which upon binding to high-affinity receptors (IL-2Ralphabetagamma) triggers mitogenesis in T cells. IL-2Ralpha expression is restricted to T cells which have r...
Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase.J. Biol. Chem. 274 , 5333, (1999)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) regulates many of the biological activities of human neutrophils. The signaling pathways via which these effects are mediated are not fully un...