2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole

Names

[ Name ]:
2-(Chloromethyl)-4-(4-Nitrophenyl)-1,3-Thiazole

[Synonym ]:
2-(chloromethyl)-4-(4-nitrophenyl)-1,3-thiazole

Biological Activity

[Description]:

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (Compound APS) has anti-cancer activity in hepatocellular carcinoma (HCC) by repression of M2 polarization of Tumor-associated macrophages (TAMs). 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole can be isolated from Astragalus propinquus Schischk[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Li C, et al. Astragalus polysacharin inhibits hepatocellular carcinoma-like phenotypes in a murine HCC model through repression of M2 polarization of tumour-associated macrophages. Pharm Biol. 2021 Dec;59(1):1533-1539.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
406.2±30.0 °C at 760 mmHg

[ Melting Point ]:
154.5ºC

[ Molecular Formula ]:
C₁₀H₇ClN₂O₂S

[ Molecular Weight ]:
254.69

[ Flash Point ]:
199.5±24.6 °C

[ Exact Mass ]:
253.991669

[ PSA ]:
86.95000

[ LogP ]:
2.71

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.638

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
34

[ Safety Phrases ]:
22-26-36/37/39-45

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%