Auramine O

Names

[ Name ]:
Auramine O

[Synonym ]:
Hydrogen chloride - 4,4'-carbonimidoylbis(N,N-dimethylaniline) (1:1:1)
Auramine Extra
Auramine O [Dye Content
Basic Yellow 2
MFCD00012484
Auramine Pure
Auramine N
Auramine O
Benzenamine, 4,4'-carbonimidoylbis[N,N-dimethyl-, chloride, hydrogen salt (1:1)
AURAMINE HYDROCHLORIDE
Aizen auramine
EINECS 219-567-2
Pyoctaninum aureum
AURAMINE
Benzenamine, 4,4'-carbonimidoylbis[N,N-dimethyl-, monohydrochloride
4,4′-(Imidocarbonyl)bis(N,N-dimethylaniline) monohydrochloride
4-[4-(dimethylamino)benzenecarboximidoyl]-N,N-dimethylaniline,hydrochloride
C.I. Basic Yellow 2
Auramine Yellow
Auramine O,biological stain
CI Basic Yellow 2
Auramin

Biological Activity

[Description]:

Auramine O is a yellow fluorescent dye and can be used to stain acid-fast bacteria. Auramine O is toxic and resistant in the environment[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Kommareddi S, et al. Nontuberculous mycobacterial infections: comparison of the fluorescent auramine-O and Ziehl-Neelsen techniques in tissue diagnosis. Hum Pathol. 1984 Nov;15(11):1085-9.

[2]. Hosseinpour S A, et al. Use of metal composite MOF‐5‐Ag2O‐NPs as an adsorbent for the removal of Auramine O dye under ultrasound energy conditions. Applied Organometallic Chemistry, 2018, 32(2): e4007.

Chemical & Physical Properties

[ Density]:
1.01g/cm3

[ Boiling Point ]:
406.2ºC at 760mmHg

[ Melting Point ]:
>250 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₇H₂₂ClN₃

[ Molecular Weight ]:
303.830

[ Flash Point ]:
199.4ºC

[ Exact Mass ]:
303.150238

[ PSA ]:
30.33000

[ LogP ]:
4.13650

[ Vapour Pressure ]:
8.31E-07mmHg at 25°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BY3675000

CHEMICAL NAME :: Aniline, 4,4'-(imidocarbonyl)bis(N,N-dimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 2465-27-2

LAST UPDATED :: 199710

DATA ITEMS CITED :: 32

MOLECULAR FORMULA :: C17-H21-N3.Cl-H

MOLECULAR WEIGHT :: 303.87

WISWESSER LINE NOTATION :: 1N1&R DYUM&R DN1&1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 480 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 gm/kg/87W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg/21W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73 gm/kg/52W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Liver - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32760 mg/kg/39W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FRANCE;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1444 No. of Facilities: 1184 (estimated) No. of Industries: 17 No. of Occupations: 22 No. of Employees: 10114 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1444 No. of Facilities: 1191 (estimated) No. of Industries: 27 No. of Occupations: 24 No. of Employees: 19092 (estimated) No. of Female Employees: 4705 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H311-H351

[ Precautionary Statements ]:
P280-P312

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R22;R24;R40

[ Safety Phrases ]:
S36/37-S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
BY3675000

[ Hazard Class ]:
6.1

[ HS Code ]:
2925290090

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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