Berbamine hydrochloride
Names
[ CAS No. ]:
6078-17-7
[ Name ]:
Berbamine hydrochloride
[Synonym ]:
6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol hydrochloride (1:1)
MFCD01076588
berbamine dihydrochloride
Biological Activity
[Description]:
[Related Catalog]:
[Target]
NF-κB
Autophagy
[In Vitro]
[In Vivo]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Boiling Point ]:
744.4ºC at 760 mmHg
[ Melting Point ]:
250-253ºC(lit.)
[ Molecular Formula ]:
C37H42Cl2N2O6
[ Molecular Weight ]:
681.65
[ Flash Point ]:
404ºC
[ PSA ]:
72.86000
[ LogP ]:
7.53720
[ Storage condition ]:
-20°C
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
22-36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2933990090
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Agric. Food Chem. 62(51) , 12407-17, (2014)
There are 20 species of the Berberidaceae family described in Chile, whose fruits are edible and show high anthocyanin and hydroxycinnamic acid levels. Berberis microphylla G. Forst, commonly known as...
Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells.Acta Pharmacol. Sin. 30(12) , 1659-65, (2009)
We sought to investigate the effect of berbamine on the growth of human multiple myeloma cell line KM3 and elucidate the mechanism of its action.MTT assay was used to determine the inhibitory effect o...
Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice.J. Asian Nat. Prod. Res. 11(3) , 219-28, (2009)
Berbamine, a natural compound from the plant Berberis amurensis, is a traditional Chinese medicine mainly used in stimulating normal hematopoiesis in clinic. Our previous studies demonstrated that ber...