(-)-DHMEQ

Names

[ Name ]:
(-)-DHMEQ

[Synonym ]:
(-)-DHM2EQ
DHMEQ
Dehydroxymethylepoxyquinomicin
2-Hydroxy-N-((1S,2S,6S)-2-hydroxy-5-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)benzamide
(-)-DHMEQ

Biological Activity

[Description]:

(–)-DHMEQ is a potent NF-κB inhibitor.

[Related Catalog]:

Signaling Pathways >> NF-κB >> NF-κB

Research Areas >> Cancer

[Target]

RelA

RelB

[In Vitro]

(–)-DHMEQ binds to cysteine 38 of RelA and cysteine 144 of RelB. (−)-DHMEQ at concentrations greater than 25 µM inhibits the LTβ-induced nuclear translocation of FLAG-RelB WT, whereas the inhibitory effect of (–)-DHMEQ on the nuclear translocation of FLAG-RelB (C144S) became weaker at the same concentrations[1].

[Cell Assay]

A549 cells transfectants stably expressing RelB WT and RelB (C144S) are preincubated with various concentrations of (-)-DHMEQ (1, 5, 10, 25, and 50 μM) for 1h and then incubated with or without LTβ (25 ng/mL) for 2 h in the presence or absence of (-)-DHMEQ.Cytoplasmic and nuclear extracts are analyzed by Western blotting[1].

[References]

[1]. Quach HT, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor κB Subunit RelB in Response to a Lymphotoxin β Stimulation. Biol Pharm Bull. 2017;40(10):1669-1677.

[2]. Kang J, et al. Exposure to a combination of formaldehyde and DINP aggravated asthma-like pathology through oxidative stress and NF-κB activation. Toxicology. 2018 May 14;404-405:49-58.

[Related Small Molecules]

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₁NO₅

[ Molecular Weight ]:
261.23000

[ Exact Mass ]:
261.06400

[ PSA ]:
102.65000

[ LogP ]:
0.29170

(-)-DHMEQ

Names

Biological Activity

Chemical & Physical Properties

Related Compounds