Papain

Names

[ Name ]:
Papain

[Synonym ]:
Velardon
Vermizym
EINECS 232-627-2
Glycylglycyl-D-tyrosyl-N-(diaminomethylene)-L-ornithine
MFCD00131791
L-Ornithine, glycylglycyl-D-tyrosyl-N-(diaminomethylene)-

Biological Activity

[Description]:

Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin

Research Areas >> Inflammation/Immunology

Natural Products >> Others

[In Vitro]

Papain is a cysteine protease of the peptidase C1 family, which is used in food, pharmaceutical, textile, and cosmetic industries.

[References]

[1]. Machado MN, et al. Bone Marrow-Derived Mononuclear Cell Therapy in Papain-Induced Experimental Pulmonary Emphysema. Front Physiol. 2018 Feb 20;9:121.

[Related Small Molecules]

Leupeptin hemisulfate salt | E-64 | PMSF | CA-074 methyl ester | LY 3000328 | Odanacatib(MK-0822) | CA 074 TFA | VBY-825 | Balicatib | Cysteine Protease inhibitor | MK-0822 | Cathepsin Inhibitor 2 | E-64c | MIV-247

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₉H₂₉N₇O₆

[ Molecular Weight ]:
451.477

[ Flash Point ]:
29 °C

[ Exact Mass ]:
451.217926

[ LogP ]:
-1.47

[ Appearance of Characters ]:
lyophilized powder | almost white

[ Index of Refraction ]:
1.652

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble1.2mg/mL | Soluble in water, insoluble in most organic solvents.

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R42;R36/37/38

[ Safety Phrases ]:
S22;S24;S26;S36/S37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
RU4950000

Articles

Lung injury-dependent oxidative status and chymotrypsin-like activity of skeletal muscles in hamsters with experimental emphysema.

BMC Musculoskelet. Disord. 14 , 39, (2013)

Peripheral skeletal muscle is altered in patients suffering from emphysema and chronic obstructive pulmonary disease (COPD). Oxidative stress have been demonstrated to participate on skeletal muscle l...

Chemomechanical caries removal in primary molars : evaluation of marginal leakage and shear bond strength in bonded restorations--an in vitro study.

J. Clin. Pediatr. Dent. 37(3) , 269-74, (2013)

To evaluate and compare the efficiency, marginal leakage and shear bond strength of Carisolv and Papacarie in primary molars.Freshly extracted 60 human carious primary molars were randomly divided int...

High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade.

PLoS ONE 6(4) , e19158, (2011)

Elevation of extracellular Ca(2+) concentration induces intracellular Ca(2+) signaling in parathyroid cells. The response is due to stimulation of the phospholipase C/Ca(2+) pathways, but the direct m...