Carboxypeptidase B
Names
[ CAS No. ]:
9025-24-5
[ Name ]:
Carboxypeptidase B
[Synonym ]:
Protaminase
N-(3-Carboxypropanoyl)alanylalanyl-N-[1-(benzylsulfanyl)-1-oxo-3-phenyl-2-propanyl]prolinamide
Peptidyl-L-lysine(L-arginine) hydrolase
Carboxypeptidase B from human pancreas
Protaminase,AEBSF treated
Prolinamide, N-(3-carboxy-1-oxopropyl)alanylalanyl-N-[2-oxo-1-(phenylmethyl)-2-[(phenylmethyl)thio]ethyl]-
Carboxypeptidase B from porcine pancreas
Biological Activity
[Description]:
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
966.7±65.0 °C at 760 mmHg
[ Molecular Formula ]:
C31H38N4O7S
[ Molecular Weight ]:
610.721
[ Flash Point ]:
538.4±34.3 °C
[ Exact Mass ]:
610.246094
[ PSA ]:
197.75000
[ LogP ]:
3.26
[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C
[ Index of Refraction ]:
1.595
[ Storage condition ]:
−20°C
MSDS
Safety Information
[ Symbol ]:
GHS07, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H315-H319-H334-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311
[ Personal Protective Equipment ]:
Eyeshields;Gloves
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
36
[ Safety Phrases ]:
26-36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
Articles
Biotechnol. Prog. 25(4) , 1064-70, (2009)
Insulin is a polypeptide hormone which is produced by the beta-cell of pancreas and controls the blood glucose level in the human body. Enzymatic modification of human proinsulin using trypsin and car...
Comparative study on activation mechanism of carboxypeptidase A1, A2 and B: First insights from steered molecular dynamics simulationsJ. Mol. Graph. Model. 38 , 298-303, (2012)
Graphical abstract
Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme.J. Med. Chem. 56(19) , 7527-35, (2013)
Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) is a zinc-containing carboxypeptidase and significantly inhibits fibrinolysis. TAFIa inhibitors are thus expected to act as profibrinolyti...