SEC inhibitor KL-1 Price from Supplier Brand ShangHai DC Chemicals Co.,Ltd on Chemsrc.com

Published date: 2023-01-15 12:56:23

CAS number: 900308-84-1

Price:
￥Inquiry/1g

Purity: 98.9%

Stocking period: 1 Day

Stock: In Stock

Detail Product Information:
SEC inhibitor KL-1 is a peptidomimetic inhibitor of super elongation complex (SEC) and transcription elongation by Pol II, disrupts cyclin T1-AFF4 interaction (Ki=3.48 uM) within SEC; disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation; attenuates the heat-shock response from Drosophila to human, reduces protein levels of SEC components AFF1 and AFF4, but not CDK9 or CCNT1 in HEK293T cells; downregulates MYC and MYC-dependent transcriptional programs in mammalian cells and delays tumor progression in mouse xenograft models of MYC-driven cancer.

Name: ShangHai DC Chemicals Co.,Ltd Recommended

Chemsrc Level: Verified

Product #: 14107

Tel: 58447131

Address: Pudong new area Jin Yu road 100#

Area: China(Mainland)

Contact: Tony Lai

Contact Phone #: 13564518121

Email: order@dcchemicals.com

Website: http://www.biomedgen.cn

Foreign Trade % of Salers: 20%

Major partners:

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