Neritaloside

Names

[ CAS No. ]:
465-13-4

[ Name ]:
Neritaloside

[Synonym ]:
Card-20(22)-enolide, 16-(acetyloxy)-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)-
(3β,5β,16β)-16-Acetoxy-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxycard-20(22)-enolide

Biological Activity

[Description]:

Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[1][2.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

Neritaloside (human tumor cell lines) has antitumor activity with mean IC50 value and mean IC70 value of 0.120 μM and 0.252 μM, respectively[1].

[In Vivo]

Neritaloside (25 mg/kg; i.p.; for 6 hours; mice of NMRI strain) exhibits central nervous system depressant activity in mice at a dose of 25 mg/kg[2. Animal Model: Mice of NMRI strain (18-22 g) [2 Dosage: 25 mg/kg Administration: Intraperitoneal injection; for 6 hours Result: Showed sedation in mice at 25 mg/kg dose.

[References]

[1]. Rashan LJ, et, al. Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum. J Ethnopharmacol. 2011 Apr 12;134(3):781-8.

[2]. Begum S, et, al. Bio-active cardenolides from the leaves of Nerium oleander. Phytochemistry. 1999 Feb;50(3):435-8.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
729.4±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₂H₄₈O₁₀

[ Molecular Weight ]:
592.718

[ Flash Point ]:
229.4±26.4 °C

[ Exact Mass ]:
592.324768

[ PSA ]:
140.98000

[ LogP ]:
3.00

[ Vapour Pressure ]:
0.0±5.4 mmHg at 25°C

[ Index of Refraction ]:
1.578

Safety Information

[ Hazard Codes ]:
Xi