Published date: 2024-07-17 15:06:26
CAS number: 755002-90-5
Name: VU 0134992
Price:
$650.0/100mg
$1200.0/250mg
$2400.0/1g
Purity: 98.0%
Stocking period: 3 Day
Stock: 3
Product Webpage: https://www.dcchemicals.com/product_show-DC23646.html
Detail Product Information:
VU0134992 (VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays; displays 9-fold selectivity for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 uM) at -120 mV; VU0134992 is greater than 30-fold selective for Kir4.1 over Kir1.1, Kir2.1, and Kir2.2, is weakly active toward Kir2.3, Kir6.2/SUR1, and Kir7.1, and is equally active toward Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 in Tl+ flux assays; causes dose-dependent diuresis, natriuresis, and kaliuresis in rats after oral treatment; VU0134992 represents the first in vivo-active tool compound for probing the therapeutic potential of Kir4.1 as a novel diuretic target for the treatment of hypertension.
Name: DC Chemicals Limited Recommended
Chemsrc Level: Verified
Product #: 34963
Tel: 58447131
Address: Jinyu Rd100, pudong
Area: China(Mainland)
Contact: Tony Cao
Contact Phone #: 13564518121
Email: sales@dcchemicals.com
Website: http://www.dcchemicals.com
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introduction:
D&C Chemicals provides a wide range of research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and Natural compounds for laboratory and scientific use.
D&C Chem has established a global network of thousands of customers from many research centers and Reagent companies in the USA, Europe and Japan.
We are the the official vendor of more than 500 universities and institutes including: Harvard University,Yale University,NIH/NCI, City of Hope ORG, PARTNERS ORG,John Hopkins University,Universit tsklinikum,Oxford University,Newcastle University,UNC,UCSF and many other universities and institutes. Our bioactive compounds received good feedback from our customers.
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Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
$650.0/100mg
$1200.0/250mg
$2400.0/1g
Contact: Yang
Product Detail: VU0134992
Name: ShangHai DC Chemicals Co.,Ltd
Area: China
Price:
$650.0/100mg
$1200.0/250mg
$2400.0/1g
Contact: Tony Lai
Product Detail: VU0134992
Name: DC Chemicals Limited
Area: China
Price:
$650.0/100mg
$1200.0/250mg
$2400.0/1g
Contact: Tony Cao
Product Detail: VU0134992
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