VU 0134992

Names

[ CAS No. ]:
755002-90-5

[ Name ]:
VU 0134992

Biological Activity

[Description]:

VU0134992 is a selective inward rectifier potassium (Kir) channel Kir4.1 blocker with an IC50 of 0.97 µM[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 0.97 µM (Kir4.1)[1]

[In Vitro]

VU0134992 is greater than 30-fold selective for Kir4.1 over Kir1.1, Kir2.1, and Kir2.2, is weakly active toward Kir2.3, Kir6.2/SUR1, and Kir7.1, and is equally active toward Kir3.1/3.2, Kir3.1/3.4, and Kir4.2[1].

[References]

[1]. Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₃₁BrN₂O₂

[ Molecular Weight ]:
411.38

Related Compounds

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