S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate

Names

[ CAS No. ]:
2905-15-9

[ Name ]:
S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate

[Synonym ]:
S-p-fluorophenyl p-fluorobenzenethiosulfonate
p,p'-Di-fluor-phenylsulfonylthiophenol
p-Fluorphenyl-p-fluorbenzolthiosulfonat
S-4-fluorophenyl 4-fluorobenzenesulfonothioate
S-4-fluorophenyl 4-fluorobenzenethiosulfonate

Biological Activity

[Description]:

Tubulin inhibitor 29 (compound 3c) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 29 shows antiproliferative effects with an IC50 value of 7.5 µM for MCF-7 cells. Tubulin inhibitor 29 inhibits tubulin assembly and bounds in the colchicine site[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[Target]

IC50: 1.2 µM (tubulin)[1].


[References]

[1]. Khodyuk RGD, et al. Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity. Bioorg Chem. 2020 Aug;101:104017.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H8F2O2S2

[ Molecular Weight ]:
286.31800

[ Exact Mass ]:
285.99300

[ PSA ]:
67.82000

[ LogP ]:
4.52660

Related Compounds