C12 NBD Globotriaosylceramide

Names

[ CAS No. ]:
2692623-26-8

[ Name ]:
C12 NBD Globotriaosylceramide

Biological Activity

[Description]:

C12 NBD galactosylceramide is a biologically active derivative of galactosylceramide that is tagged with a fluorescent C12 nitrobenzoxadiazole (C12 NBD) group. C12 NBD galactosylceramide has been used to detect ceramide trihexoside[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

C12 NBD globotriaosylceramide accumulates in human umbilical vascular endothelial cells (HUVECs) treated with the α-galactosidase A inhibitor in a concentration-dependent manner[2].

[References]

[1]. Kassiani Kytidou, et al. Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease. J Biol Chem. 2018 Jun 29;293(26):10042-10058.

[2]. Janet Hsu, et al. Enhanced endothelial delivery and biochemical effects of α-galactosidase by ICAM-1-targeted nanocarriers for Fabry disease. J Control Release. 2011 Feb 10;149(3):323-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C54H91N5O21

[ Molecular Weight ]:
1146.32

Related Compounds