mGluR2 modulator 1

Names

[ CAS No. ]:
2671063-84-4

[ Name ]:
mGluR2 modulator 1

Biological Activity

[Description]:

mGluR2 modulator 1 (compound 95) is a potent and BBB-penetrated mGluR2 (metabotropic glutamate receptor-2) positive allosteric modulator, with an EC50 of 0.03 μM. mGluR2 modulator 1 can be used for psychosis research[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

mGluR2:0.03 ± 0.0 μM (EC50)


[References]

[1]. Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs). Eur J Med Chem. 2020 Jan 15;186:111881.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H20F3N3O3

[ Molecular Weight ]:
419.40

Related Compounds