A1AR antagonist 3

Names

[ CAS No. ]:
2413257-73-3

[ Name ]:
A1AR antagonist 3

Biological Activity

[Description]:

A1AR antagonist 3 (compound 13) is a selective adenosine 1 (A1) receptor antagonist with Kis of 9.69 nM and 0.529 nM for human A1 and rat A1, respectively. A1AR antagonist 3 can be used for researching neurological diseases[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

human A1:9.69 nM (Ki)

rat A1:0.529 nM (Ki)


[References]

[1]. Abdelrahman A, et al. Substituted 4-phenylthiazoles: Development of potent and selective A1, A3 and dual A1/A3 adenosine receptor antagonists. Eur J Med Chem. 2020;186:111879.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H20N2O3S

[ Molecular Weight ]:
428.50

Related Compounds