PPARγ/δ modulator 1

Names

[ CAS No. ]:
2089159-00-0

[ Name ]:
PPARγ/δ modulator 1

Biological Activity

[Description]:

PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with Ki values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC50 of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Research Areas >> Metabolic Disease

[Target]

PPARδ:14.4 nM (Ki)

PPARγ:5.31 μM (Ki)


[References]

[1]. An S, et al. Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. Bioorg Med Chem. 2020 Jan 1;28(1):115226.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H18ClIN6O3Se

[ Molecular Weight ]:
607.69

Related Compounds