NEP-IN-2

Names

[ CAS No. ]:
145775-14-0

[ Name ]:
NEP-IN-2

[Synonym ]:
FORMATEROL FUMATATE
ForMaterol FuMarate
N-[2-mercaptomethyl-3-(2-methylphenyl)propioyl]-methionine
Aformoterol
Eformoterol fumarate
FarMeterol
(R,R)-formoterol fumarate
N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-(4-methoxyphenyl)-1-methylethyl]-amino]ethyl]phenyl]formamide
N-[2-mercaptomethyl-3-(2-methylphenyl)propionyl]-methionine
NEP-IN-2

Biological Activity

[Description]:

NEP-IN-2 is an inhibitor of neutral endopeptidase, used in the research of proliferation in atherosclerosis, restenosis.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin
Research Areas >> Cardiovascular Disease

[Target]

Neutral endopeptidase[1]


[In Vitro]

NEP-IN-2 is an inhibitor of neutral endopeptidase (NEP), used in the research of proliferation in atherosclerosis, restenosis induced by angioplasty or vascular reconstructive surgery, glomerulonephritis, glomerulosclerosis or other diseases involving vascular cell proliferation[1].

[References]

[1]. Davis, Harry R., et al. Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating and preventing myointimal proliferation. EP0533084 Kind Code: A1


[Related Small Molecules]

Sacubitril/valsartan (LCZ696) | AHU 377 | Sacubitrilat | Phosphoramidon disodium salt | Racecadotril | Candoxatril | NEP-In-1 | SQ28603

Chemical & Physical Properties

[ Density]:
1.204g/cm3

[ Boiling Point ]:
603ºC at 760 mmHg

[ Molecular Formula ]:
C16H23NO3S2

[ Molecular Weight ]:
341.48900

[ Flash Point ]:
318.5ºC

[ Exact Mass ]:
341.11200

[ PSA ]:
133.99000

[ LogP ]:
3.24630

[ Vapour Pressure ]:
2.16E-15mmHg at 25°C

[ Index of Refraction ]:
1.578

Related Compounds