Amylin (20-29) (human)

Names

[ Name ]:
Amylin (20-29) (human)

[Synonym ]:
AMYLIN FRAGMENT 20-29 HUMAN
SER-ASN-ASN-PHE-GLY-ALA-ILE-LEU-SER-SER
diabetes associated peptide fragment 20-29 human
SNNFGAILSS

Biological Activity

[Description]:

Amylin (20-29) (human) is the fragment of human islet amyloid polypeptide (hIAPP) or Amylin. Amylin is a 37-residue hormone. Amylin (20-29) (human) is responsible for the amyloidogenic propensities of the full length protein. Amylin (20-29) (human) can be transformed into its corresponding peptoid and retropeptoid sequences, to obtain beta-sheet breaker peptides as amyloid inhibitors[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Kapurniotu A, et al. Structure-based design and study of non-amyloidogenic, double N-methylated IAPP amyloid core sequences as inhibitors of IAPP amyloid formation and cytotoxicity. J Mol Biol. 2002 Jan 18;315(3):339-50.

[2]. Elgersma RC, et al. Transformation of the amyloidogenic peptide amylin(20-29) into its corresponding peptoid and retropeptoid: access to both an amyloid inhibitor and template for self-assembled supramolecular tapes. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1837-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₃H₆₈N₁₂O₁₆

[ Molecular Weight ]:
1009.07

[ Exact Mass ]:
1008.49000

[ PSA ]:
472.09000

Safety Information

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3

Related Compounds

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